Melanotan-2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone. Developed in the 1980s, Melanotan-2 has been shown to increase sexual arousal, reduce compulsive/addictive behavior, curb hunger and increase melanin production. Research has shown the peptide to stimulate melanocytes therefore producing increased skin pigmentation and may help to combat autism when used during early childhood development.

Melanotan II is a potent analogue of α-MSH that exerts its effects through the melanocortin receptor system, primarily affecting pigmentation, appetite, and sexual function. Its action involves a complex interplay of receptor activation, signal transduction via the cAMP pathway, and the regulation of key genes involved in melanin production. Through these mechanisms, MT-II influences several physiological processes, making it a molecule of significant interest in both therapeutic and research contexts.

For Research Use Only

The Role of Leptin-Melanocortin System and Human Weight Regulation: Lessons from Experiments of Nature

MT-II Induces Penile Erection via Brain and Spinal Mechanisms