IGF-1 LR3 – 1mg

IGF-1 LR3, a highly potent variant of the naturally occurring Insulin-like Growth Factor 1 (IGF-1), is engineered to amplify IGF-1’s anabolic activities with a pronounced efficacy in muscle and fat metabolism. By incorporating modifications such as the substitution of Arginine for Glutamic Acid at the third position and extending the peptide’s N-terminus, IGF-1 LR3 exhibits an enhanced biological activity and a significantly prolonged half-life of approximately 20-30 hours in the human body. These alterations not only extend its duration of action but also enable IGF-1 LR3 to circumvent binding with IGF-binding proteins, which typically impede the biological availability and efficacy of IGF-1.

The mechanism of action of IGF-1 LR3 is multifaceted, involving the direct stimulation of muscle cells and other tissues by binding to the IGF-1 receptor, which activates intracellular signaling pathways essential for muscle growth and differentiation. Notably, IGF-1 LR3 enhances muscle sensitivity to insulin, thereby promoting glucose uptake and utilization while simultaneously reducing fat storage. This unique action supports the dual objectives of muscle hypertrophy and fat reduction.

​In muscle tissue, IGF-1 LR3 is instrumental in increasing the DNA and RNA synthesis, which are crucial for protein synthesis and muscle cell proliferation, leading to hyperplasia (increase in the number of muscle cells) and hypertrophy (enlargement of existing muscle cells). This results in an overall increase in muscle mass and strength, alongside improved muscle recovery and reduced recovery times post-exercise due to its regenerative properties.

​Moreover, IGF-1 LR3’s ability to modulate glucose metabolism—by restricting glucose transport into cells—encourages the use of fat as an energy source, facilitating significant fat loss. This metabolic shift not only enhances lean muscle gains but also contributes to a more efficient energy use within the body.

​The clinical applications of IGF-1 LR3 span across various growth deficiencies and conditions requiring anabolic support, including hormone deficiencies leading to short stature, Turner Syndrome, muscle-wasting diseases, and conditions associated with pituitary tumors. The therapeutic benefits of IGF-1 LR3 are not limited to growth stimulation; it also encompasses the enhancement of lean muscle mass, improvement in athletic performance, reduction in body fat, upregulation of antioxidant benefits, and strengthening of ligaments.

IGF-1 LR3 represents a significant advancement in peptide therapy, offering a robust anabolic tool with extended half-life and enhanced potency. Its dual action on muscle growth and fat metabolism makes it a highly sought-after compound in fields requiring accelerated muscle development and recovery, alongside metabolic optimization for fat loss.

For Research Use Only

Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophy.

Expression of IGF-1 Isoforms after Exercise-induced Muscle Damage in Humans