Epithalon, also known as Epitalon or Epithalone, is a tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly. This sequence mimics that of a natural peptide, epithalamin, which is extracted from the pineal gland of bovines. Epithalon is primarily recognized for its potential role in the modulation of telomerase activity, a key enzyme involved in the maintenance and elongation of telomeres.
Chemically, Epithalon is categorized as a polypeptide, consisting of four amino acid residues: alanine, glutamic acid, aspartic acid, and glycine. The peptide bonds formed between these amino acids result in a molecule with a low molecular weight, which enables it to cross the blood-brain barrier. The structure of Epithalon is characterized by its linear, non-branching arrangement, allowing it to interact with specific receptors and enzymatic complexes within cells.
Functionally, Epithalon is hypothesized to exert its biological effects primarily through the activation of telomerase, an enzyme that adds specific DNA sequence repeats (“TTAGGG” in all vertebrates) to the 3′ end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. This activity is crucial in maintaining genomic stability and preventing chromosomal degradation, thereby potentially influencing cellular aging and longevity.
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Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice
Test Report Epithalon 10mg Purity & Quantity
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